Science Programmes
The use of biological agents, how can we improve them?
Session 4
Immunology
Dr S. Grigoriadou, Barts and The London NHS Trust/Queen Mary University of London
The use of biological therapies has now become routine practice for many human diseases. In the context of inflammatory arthritides the use of these therapies not only revolutionised the approach to treatment but also facilitated our understanding about their pathogenesis.
Currently available therapies for Rheumatoid arthritis include anti-TNFα inhibitors and agents targeting B-cells and the IL-6 receptor, each of them with a different mechanism of action. Despite their widespread use and high effectiveness, not all patients respond to this type of treatment for reasons that are poorly understood at present. In addition, the use of these high cost agents is not without side effects and the need for improved management strategies is now apparent. Current progress in the understanding and targeted treatment with these agents will be discussed.
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